Organische Chemie (Gillingham)

Lu, Xinyan et al. (2025) ‘Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations’, ACS Chemical Biology. 29.04.2025, p. Online ahead of print. Available at: https://doi.org/10.1021/acschembio.5c00111.

Sauter, Basilius et al. (2025) ‘Challenges and Opportunities in DNA Encoded Library Screens’, CHIMIA. 26.03.2025, 79(3), pp. 158–161. Available at: https://doi.org/10.2533/chimia.2025.158.

Cai, Pinwen et al. (2025) ‘A method to identify small molecule/protein pairs susceptible to protein ubiquitination by the CRBN E3 ligase’, Chemrxiv [Preprint]. Cambridge University Press (Chemrxiv). Available at: https://doi.org/10.26434/chemrxiv-2024-8v8km-v2.

Cai, Pinwen et al. (2025) ‘A method to identify small molecule/protein pairs susceptible to protein ubiquitination by the CRBN E3 ligase’, Chemical Science. 31.03.2025, p. Online ahead of print. Available at: https://doi.org/10.1039/d5sc01251a.

Lu, Xinyan (2024) A chemical degron system for exploring PALB2 synthetic lethal combinations. Doctoral Thesis. University of Basel.

Cai, Pinwen et al. (2024) ‘A method to identify small molecule/protein pairs susceptible to protein ubiquitination’, Chemrxiv [Preprint]. Cambridge University Press (Chemrxiv). Available at: https://doi.org/10.26434/chemrxiv-2024-8v8km.

Buchholz, T.A. (2024) Helically-shaped peri-oligo-naphthylenes and organophotocatalytic flow oxygenation of phenols . Doctoral Thesis.

Cai, P. (2024) Functional selection of DNA-encoded library. Doctoral Thesis.

Dagher, K. (2024) A transcriptional reporting system for sensing interactions of small molecules with proteins. Doctoral Thesis.

Gillingham, Dennis G and Sauter, Basilius (2024) ‘3.2.3.1 Macrocyclic DELs’, in Scheuermann, J.; Li, Y. (ed.), Fürstner, A.;Carreira, E. M.;Faul, M.;Kobayashi, S.;Koch, G.;Molander, G. A.;Nevado, C.;Trost, B. M.;You, S.-L. (tran.) DNA-Encoded Libraries. 1 edn. Stuttgart: Georg Thieme Verlag KG (Science of Synthesis), p. 561–. Available at: https://doi.org/10.1055/sos-sd-241-00235.

Jauslin, W.T. (2024) Exploring PI3Ks and related kinases for targeted protein degradation. Doctoral Thesis.

Lüthi, Hans P. et al. (2024) ‘The Swiss Summer School on Chemical Biology, Bergün/Bravuogn, August 25–29, 2024’, in Chimia, pp. 793–796. Available at: https://doi.org/10.2533/chimia.2024.793.

Wen, X. (2024) Synthetic reagents for in vitro enzymatic and protein alkylation. Doctoral Thesis.

Schneider, Lukas A. et al. (2023) ‘Recording Binding Information Directly into DNA-Encoded Libraries Using Terminal Deoxynucleotidyl Transferase’, Journal of the American Chemical Society. 13.09.2023, 145(38), pp. 20874–20882. Available at: https://doi.org/10.1021/jacs.3c05961.

Coomar, Seemon et al. (2023) ‘Overlaid Transcriptional and Proteome Analyses Identify Mitotic Kinesins as Important Targets of Arylsulfonamide-Mediated RBM39 Degradation’, Molecular Cancer Research, 21, pp. OF1–OF11. Available at: https://doi.org/10.1158/1541-7786.MCR-22-0541.

Auberson, Yves P. et al. (2023) ‘An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society**’, ChemMedChem, 18. Available at: https://doi.org/10.1002/cmdc.202300014.

Baron, Leeroy et al. (2023) ‘PSL Chemical Biology Symposia Third Edition: A Branch of Science in its Explosive Phase’, ChemBioChem, 24. Available at: https://doi.org/10.1002/cbic.202300093.

Schneider, L.A. (2023) A novel selection approach for DNA-encoded libraries using terminal deoxynucleotidyl transferase. Doctoral Thesis.

Vogel, C.H. (2023) Repurposing MGMT as a kill switch in chemical biology and as a novel mode of action in protein degradation. Doctoral Thesis.

Capomolla, Simona S. et al. (2022) ‘A Tail Does Not Always Make a Difference: Assembly of cds Nets from Co(NCS)2 and 1,4-bis(n-Alkyloxy)- 2,5-bis(3,2′:6′,3′′-terpyridin-4′-yl)benzene Ligands’, Molecules. 05.08.2022, 27(15), p. 4995. Available at: https://doi.org/10.3390/molecules27154995.

Leisinger, F. (2022) How structure guides function: ergothioneine anabolism and catabolism formylglycine generating enzyme methyl transferases. Doctoral Thesis.

Murawska, Gosia M. et al. (2022) ‘Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron’, ACS Chemical Biology [Preprint]. Available at: https://doi.org/10.1021/acschembio.1c00771.

Duca, Maria et al. (2021) ‘The Chemical Biology-Medicinal Chemistry Continuum: EFMC′s Vision’, ChemBioChem, 22, pp. 2823–2825. Available at: https://doi.org/10.1002/cbic.202100319.

Gillingham, Dennis (2021) ‘Fantastic molecular glues and where to find them’, Chimia, 75, pp. 439–441. Available at: https://doi.org/10.2533/CHIMIA.2021.439.

Cai, Pinwen et al. (2021) ‘Building Boron Heterocycles into DNA-Encoded Libraries’, Organic letters, 23(22), pp. 8772–8776. Available at: https://doi.org/10.1021/acs.orglett.1c03262.

Murawska, M.M. (2021) Study and exploitation of the direct DNA repair protein O6-MethylGuanine MethylTransferase – MGMT . Doctoral Thesis.

Sauter, Basilius et al. (2021) ‘An assessment of the mutational load caused by various reactions used in DNA encoded libraries’, Bioorganic & Medicinal Chemistry. 15.11.2021, 52, p. 116508. Available at: https://doi.org/10.1016/j.bmc.2021.116508.

Coomar, S. (2020) Investigations around RBM39 degrading arylsulfonamides. Doctoral Thesis.

Kilaj, Ardita et al. (2020) ‘Quantum-chemistry-aided identification, synthesis and experimental validation of model systems for conformationally controlled reaction studies: separation of the conformers of 2,3-dibromobuta-1,3-diene in the gas phase’, Physical Chemistry Chemical Physics, 22(24), pp. 13431–13439. Available at: https://doi.org/10.1039/d0cp01396j.

Sabatino, V. (2020) Applications of Aqueous Olefin Metathesis in Chemical Biology and Drug Discovery. Doctoral Thesis.

Sauter, B. (2020) Applications of Next Generation Sequencing in the Field of Chemical Biology. Doctoral Thesis.

Sauter, Basilius and Gillingham, Dennis (2020) ‘DNA Damaging Agents in Chemical Biology and Cancer’, Chimia, 74(9), pp. 693–698. Available at: https://doi.org/10.2533/chimia.2020.693.

Słabicki, Mikołaj et al. (2020) ‘The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K’, Nature, 585(7824), pp. 293–297. Available at: https://doi.org/10.1038/s41586-020-2374-x.

Stress, Cedric J. et al. (2019) ‘Eine DNA‐kodierte Molekülbibliothek mit Elementen natürlicher Makrocyclen’, Angewandte Chemie. 02.04.2019, 131(28), pp. 9671–9675. Available at: https://doi.org/10.1002/ange.201902513.

Geigle, Stefanie, Rasale, Dnyaneshwar B. and Gillingham, Dennis (2019) ‘Synthesis of Various Water Soluble and Stable Copper Complexes Bearing N-Heterocyclic Carbene Ligands and Their Activity in DNA Alkylation’, Helvetica Chimica Acta, 102. Available at: https://doi.org/10.1002/hlca.201800183.

Räz, Michael H. et al. (2019) ‘High Sensitivity of Human Translesion DNA Synthesis Polymerase κ to Variation in O6-Carboxymethylguanine Structures’, ACS Chemical Biology, 14(2), pp. 214–222. Available at: https://doi.org/10.1021/acschembio.8b00802.

Stress, C. (2019) Aqueous synthetic methods and their applications in DNA-encoded chemical libraries. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-007110690.

Stress, Cedric J. et al. (2019) ‘A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles’, Angewandte Chemie International Edition, 58(28), pp. 9570–9574. Available at: https://doi.org/10.1002/anie.201902513.

Wang, Yu et al. (2019) ‘Nanopore Sequencing Accurately Identifies the Mutagenic DNA Lesion O; 6; -Carboxymethyl Guanine and Reveals Its Behavior in Replication’, Angewandte Chemie International Edition, 58(25), pp. 8432–8436. Available at: https://doi.org/10.1002/anie.201902521.

Handel AE et al. (2018) ‘Comprehensively Profiling the Chromatin Architecture of Tissue Restricted Antigen Expression in Thymic Epithelial Cells Over Development’, Frontiers in Immunology. 19.09.2018, 9, p. 2120. Available at: https://doi.org/10.3389/fimmu.2018.02120.

Gillingham, Dennis and Rasale, Dnyaneshwar (2018) ‘Direct and Selective Modification of RNA - An Open Challenge in Nucleic Acid Chemistry’, Chimia, 72(11), pp. 777–781. Available at: https://doi.org/10.2533/chimia.2018.777.

Rasale, Dnyaneshwar et al. (2018) ‘A new water soluble copper N-heterocyclic carbene complex delivers mild O6G-selective RNA alkylation’, Chemical Communications, 54(66), pp. 9174–9177. Available at: https://doi.org/10.1039/c8cc04476g.

Sauter, Basilius and Gillingham, Dennis (2018) ‘Profiling the Nucleobase and Structure Selectivity of Anticancer Drugs and other DNA Alkylating Agents by RNA Sequencing’, ChemBioChem, 19(15), pp. 1638–1642. Available at: https://doi.org/10.1002/cbic.201800235.

Geigle, S.N. (2017) Exploring copper(I) as a catalyst for nucleic acid alkylation. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-006809316.

Geigle, Stefanie et al. (2017) ‘Copper carbenes alkylate guanine chemoselectively through a substrate directed reaction’, Chemical Science, 8(1), pp. 499–506. Available at: https://doi.org/10.1039/c6sc03502g.

Gillingham, Dennis and Sauter, Basilius (2017) ‘Genomic Studies Reveal New Aspects of the Biology of DNA Damaging Agents’, ChemBioChem, 18(24), pp. 2368–2375. Available at: https://doi.org/10.1002/cbic.201700520.

Fei, Na (2016) Diazo compounds for the customization of important biomolecules. Dissertation. Universität Basel.

Fei, N. (2016) Diazo compounds for the customization of important biomolecules. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-006699787.

Fei, Na, Sauter, Basilius and Gillingham, Dennis (2016) ‘The pKa of Bronsted acids controls their reactivity with diazo compounds’, Journal of the Chemical Society, Chemical Communications, 52(47), pp. 7501–7504. Available at: https://doi.org/10.1039/c6cc03561b.

Gillingham, Dennis (2016) ‘The role of boronic acids in accelerating condensation reactions of [small alpha]-effect amines with carbonyls’, Organic & Biomolecular Chemistry, 14(32), pp. 7606–7609. Available at: https://doi.org/10.1039/c6ob01193d.

Gillingham, Dennis, Geigle, Stefanie and von Lilienfeld, O. Anatole (2016) ‘Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics’, Chemical Society Reviews, 45(9), pp. 2637–55. Available at: https://doi.org/10.1039/c5cs00271k.

Mayer, C. E. et al. (2016) ‘Dynamic spatio-temporal contribution of single beta5t+ cortical epithelial precursors to the thymus medulla’, Eur J Immunol, 46(4), pp. 846–56. Available at: https://doi.org/10.1002/eji.201545995.

Stress, Cedric, Schmidt, Pascal and Gillingham, Dennis (2016) ‘Comparison of boron-assisted oxime and hydrazone formations leads to the discovery of a fluorogenic variant’, Organic & Biomolecular Chemistry, 14(24), pp. 5529–33. Available at: https://doi.org/10.1039/c6ob00168h.

Zuklys, S. et al. (2016) ‘Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells’, Nat Immunol, 17(10), pp. 1206–1215. Available at: https://doi.org/10.1038/ni.3537.

Bachmann, D.G. (2015) Studies towards the total synthesis of lomaiviticin and kinamycin, new entries towards locked nucleic acids, development of modifiable Rh(II) catalysts with high activity and synthesis of hydroxylamines by direct alcohol amination. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-006422185.

Bachmann, Daniel Gerardo (2015) Studies towards the total synthesis of lomaiviticin and kinamycin, new entries towards locked nucleic acids, development of modifiable Rh(II) catalysts with high activity and synthesis of ... Dissertation. Universität Basel.

Bachmann, Daniel et al. (2015) ‘Modular ligands for dirhodium complexes facilitate catalyst customization’, Advanced Synthesis and Catalysis, 357(9), pp. 2033–2038. Available at: https://doi.org/10.1002/adsc.201500050.

Gillingham, Dennis and Shahid, Ramla (2015) ‘Catalysts for RNA and DNA modification’, Current Opinion in Chemical Biology, 25, pp. 110–4. Available at: https://doi.org/10.1016/j.cbpa.2014.12.025.

Schmidt, Pascal Jarno (2015) New strategies in bioconjugation - chemical modification of nucleic acids and peptides. Dissertation. Universität Basel.

Schmidt, P.J. (2015) New strategies in Bioconjugation : chemical modification of nucleic acids and peptides. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-006615291.

Schmidt, Pascal, Stress, Cedric and Gillingham, Dennis (2015) ‘Boronic acids facilitate rapid oxime condensations at neutral pH’, Chemical Science, 6(6), pp. 3329–3333. Available at: https://doi.org/10.1039/c5sc00921a.

Tishinov, K. (2015) New catalytic strategies for DNA and RNA alkylation using rhodium (II) and copper (I) carbenes - a versatile tool for applications in chemical biology. Doctoral Thesis. Available at: https://doi.org/10.5451/unibas-006359399.

Tishinov, Kiril and Gillingham, Dennis (2015) ‘Synthesis of New Alkylated Mononucleotide Analogues and Their Repair Proficiency by the Prokaryotic DNA Repair Protein AlkB’, Synlett, 26(19), pp. 2720–2723. Available at: https://doi.org/10.1055/s-0035-1560491.

Schmidt, Pascal et al. (2014) ‘Dialdehydes Lead to Exceptionally Fast Bioconjugations at Neutral pH by Virtue of a Cyclic Intermediate’, Angewandte Chemie International Edition, 53(41), pp. 10928–31. Available at: https://doi.org/10.1002/anie.201406132.

Tishinov, Kiril (2014) New catalytic strategies for DNA and RNA alkylation using rhodium(II) and copper(I) carbenes - a versatile tool for applications in chemical biology. Dissertation. Universität Basel.

Bachmann, Daniel G., Wittwer, Christopher C. and Gillingham, Dennis G. (2013) ‘Stereoselective Heck Reactions with Vinyl Sulfoxides, Sulfides and Sulfones’, Advanced Synthesis and Catalysis, 355(18), pp. 3703–3707. Available at: https://doi.org/10.1002/adsc.201300678.

Gillingham, Dennis and Fei, Na (2013) ‘Catalytic X-H insertion reactions based on carbenoids’, Chemical Society Reviews, 42(12), pp. 4918–31. Available at: https://doi.org/10.1039/c3cs35496b.

Gillingham, Dennis and Tishinov, Kiril (2013) ‘Synthesis of nucleic acid polymers with non-canonical nucleobases’, Synlett, 24(8), pp. 893–897. Available at: https://doi.org/10.1055/s-0032-1318493.

Tishinov, Kiril, Fei, Na and Gillingham, Dennis (2013) ‘Cu(I)-catalysed N-H insertion in water: a new tool for chemical biology’, Chemical Science, 4(12), pp. 4401–4406. Available at: https://doi.org/10.1039/c3sc51363g.

Gillingham, Dennis, Martinez, Alexandre and Pianowski, Zbigniew (2012) ‘Report from the 47th EUCHEMS Conference on Stereochemistry : The Bürgenstock Conference’, Chimia, 66(11), pp. 873–875. Available at: https://doi.org/10.2533/chimia.2012.873.

Stallforth, Pierre et al. (2012) ‘De novo chemoenzymatic synthesis of sialic acid’, Chemical Communications, 48(98), pp. 11987–9. Available at: https://doi.org/10.1039/c2cc37305j.

Tishinov, Kiril et al. (2012) ‘Structure-selective catalytic alkylation of DNA and RNA’, Angewandte Chemie International Edition, 51(48), pp. 12000–4. Available at: https://doi.org/10.1002/anie.201205201.