Synthesis of Functional Modules (Tiefenbacher)

Li, Tian-Ren et al. (2025) ‘Tetrafluororesorcin[4]arene Hexameric Capsule Enables the Expansion of the Reactivity Space in Supramolecular Catalysis’, Journal of the American Chemical Society. 05.02.2025, p. Online ahead of print. Available at: https://doi.org/10.1021/jacs.4c17029.

Lu, Yiheng et al. (2025) ‘Site-selective C(sp3)–H oxidation of alkyl substrates devoid of functional handles’, Chem. 25.02.2025, p. Online ahead of print. Available at: https://doi.org/10.1016/j.chempr.2025.102442.

Fiorini, Luca et al. (2025) ‘Unusual Reaction of Isocyanides with Aromatic Aldehydes Catalyzed by a Supramolecular Capsule’, Chemistry - A European Journal. 23.12.2024, p. Online ahead of print. Available at: https://doi.org/10.1002/chem.202404061.

Syntrivanis, Leonidas‐Dimitrios and Tiefenbacher, Konrad (2024) ‘Reaktivität in Molekularen Gefäßen: Beschleunigungsmodi und Arten der Erzielbaren Selektivität’, Angewandte Chemie. 19.09.2024, 136(49). Available at: https://doi.org/10.1002/ange.202412622.

Syntrivanis, Leonidas‐Dimitrios and Tiefenbacher, Konrad (2024) ‘Reactivity Inside Molecular Flasks: Acceleration Modes and Types of Selectivity Obtainable’, Angewandte Chemie International Edition. 19.09.2024, 63(49). Available at: https://doi.org/10.1002/anie.202412622.

Persiani, Giacomo et al. (2024) ‘Catalyzing the Enantioselective Tail‐to‐Head Terpene Cyclization Inside Optically Active Hexameric Resorcin[4]arene Capsules: A Surprising Odd‐Even Effect of the Catalyst’, European Journal of Organic Chemistry. 15.08.2024, 27(47). Available at: https://doi.org/10.1002/ejoc.202400923.

Rodríguez-Robles, Emilio et al. (2024) ‘Rational design of a bacterial import system for new-to-nature molecules’, Metabolic Engineering. 25.05.2024, 85, pp. 26–34. Available at: https://doi.org/10.1016/j.ymben.2024.05.005.

Lu, Yiheng et al. (2024) ‘Site-Selective C(sp3)–H Oxidation of Aliphatic Substrates Devoid of Functional Groups’, Chemrxiv [Preprint]. Cambridge University Press (Chemrxiv). Available at: https://doi.org/10.26434/chemrxiv-2024-5gv6d.

Strassberger, Alexander Felix et al. (2024) ‘Quinoacridane[4]arenes─Very Large Conformationally Restricted Macrocycles’, Organic Letters. 25.07.2024, 26(31), pp. 6720–6724. Available at: https://doi.org/10.1021/acs.orglett.4c02406.

Li, T.-R. et al. (2024) ‘Window[1]resorcin[3]arenes: A Novel Macrocycle Able to Self-Assemble to a Catalytically Active Hexameric Cage’, JACS Au, 4(5), pp. 1901–1910. Available at: https://doi.org/10.1021/jacsau.4c00097.

Muthwill, Moritz S. et al. (2024) ‘Planar Polymer Membranes Accommodate Functional Self-Assembly of Inserted Resorcinarene Nanocapsules’, ACS Applied Materials and Interfaces. 29.02.2024, 16(10), pp. 13291–13304. Available at: https://doi.org/10.1021/acsami.3c18687.

Cornu, Ivan, Syntrivanis, Leonidas-Dimitrios and Tiefenbacher, Konrad (2024) ‘Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst’, Nature Protocols, 19(2), pp. 313–339. Available at: https://doi.org/10.1038/s41596-023-00919-3.

Klucznik, Tomasz et al. (2023) ‘Computational prediction of complex cationic rearrangement outcomes’, Nature. 15.11.2023, 625, p. pages 508–515. Available at: https://doi.org/10.1038/s41586-023-06854-3.

Schmid, Dario et al. (2023) ‘Exploring the Glycosylation Reaction Inside the Resorcin[4]arene Capsule’, Journal of Organic Chemistry, 88(20), pp. 14515–14526. Available at: https://doi.org/10.1021/acs.joc.3c01547.

Zenka, Mattias et al. (2023) ‘A Water- and Base-Stable Iminopyridine-Based Cage That Can Bind Larger Organic Anions’, European Journal of Inorganic Chemistry, 26(15). Available at: https://doi.org/10.1002/ejic.202300110.

Némethová, Ivana, Schmid, Dario and Tiefenbacher, Konrad (2023) ‘Supramolekulare Kapselkatalyse ermöglicht die Erforschung des von der Natur unerschlossenen chemischen Raums der Terpenoide’, Angewandte Chemie. 02.02.2023, 135(14). Available at: https://doi.org/10.1002/ange.202218625.

Némethová, Ivana, Schmid, Dario and Tiefenbacher, Konrad (2023) ‘Supramolecular Capsule Catalysis Enables the Exploration of Terpenoid Chemical Space Untapped by Nature’, Angewandte Chemie - International Edition. 02.02.2023, 62(14). Available at: https://doi.org/10.1002/anie.202218625.

Li, Tian-Ren, Piccini, GiovanniMaria and Tiefenbacher, Konrad (2023) ‘Supramolecular Capsule-Catalyzed Highly β-Selective Furanosylation Independent of the SN1/SN2 Reaction Pathway’, Journal of the American Chemical Society, 145(7), pp. 4294–4303. Available at: https://doi.org/10.1021/jacs.2c13641.

Pfeuffer‐Rooschüz, Jonathan et al. (2022) ‘Megalo‐Kavitanden: Synthese von Acridan[4]arenen und Bildung großer, tiefer Kavitanden für die selektive C 70 ‐Aufnahme’, Angewandte Chemie. 04.08.2022, 134(42). Available at: https://doi.org/10.1002/ange.202209885.

Li, Tian-Ren et al. (2022) ‘Publisher Correction: Mimicry of the proton wire mechanism of enzymes inside a supramolecular capsule enables β-selective O-glycosylations (Nature Chemistry, (2022), 14, 9, (985-994), 10.1038/s41557-022-00981-6)’, Nature Chemistry, 14(9), p. 1086. Available at: https://doi.org/10.1038/s41557-022-01040-w.

Sokolova, Daria, Piccini, GiovanniMaria and Tiefenbacher, Konrad (2022) ‘Enantioselektive Tail‐to‐Head‐Terpencyclisierungen durch optisch aktive hexamere Resorcin[4]aren‐Kapselderivate’, Angewandte Chemie. 24.03.2022, 134(25). Available at: https://doi.org/10.1002/ange.202203384.

Chen, Hao et al. (2022) ‘Decoded fingerprints of hyperresponsive, expanding product space: polyether cascade cyclizations as tools to elucidate supramolecular catalysis’, Chemical Science, 13(35), pp. 10273–10280. Available at: https://doi.org/10.1039/d2sc03991e.

Huck, Fabian et al. (2022) ‘Expanding the Protecting Group Scope for the Carbonyl Olefin Metathesis Approach to 2,5-Dihydropyrroles’, Journal of Organic Chemistry, 87(1), pp. 419–428. Available at: https://doi.org/10.1021/acs.joc.1c02447.

Knezevic, Melina and Tiefenbacher, Konrad (2022) ‘Tweezer-Based C-H Oxidation Catalysts Overriding the Intrinsic Reactivity of Aliphatic Ammonium Substrates’, Chemistry - A European Journal, 29(13), p. e202203480. Available at: https://doi.org/10.1002/chem.202203480.

Li, Tian-Ren et al. (2022) ‘Mimicry of the proton wire mechanism of enzymes inside a supramolecular capsule enables beta-selective O-glycosylations’, Nature Chemistry, 14(9), pp. 985–994. Available at: https://doi.org/10.1038/s41557-022-00981-6.

Pfeuffer-Rooschüz, Jonathan et al. (2022) ‘Megalo-Cavitands: Synthesis of Acridane[4]arenes and Formation of Large, Deep Cavitands for Selective C70 Uptake’, Angewandte Chemie International Edition, 61(42), p. e202209885. Available at: https://doi.org/10.1002/anie.202209885.

Sokolova, Daria, Piccini, GiovanniMaria and Tiefenbacher, Konrad (2022) ‘Enantioselective Tail-to-Head Terpene Cyclizations by Optically Active Hexameric Resorcin[4]arene Capsule Derivatives’, Angewandte Chemie International Edition, 61(25), p. e202203384. Available at: https://doi.org/10.1002/anie.202203384.

Nemat, Suren J. et al. (2021) ‘Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces’, Chemical Communications, 57(38), pp. 4694–4697. Available at: https://doi.org/10.1039/d1cc00223f.

Li, Tian-Ren et al. (2021) ‘Hydrogen Bond Synchronized Dual Activation Enables the Unified β-Selective O-Glycosylation Inside a Molecular Capsule’, Chemrixv [Preprint]. Cambridge University Press (Chemrixv). Available at: https://doi.org/10.26434/chemrxiv.14199443.v1.

Hao, Xiaoyu et al. (2021) ‘Bioinspired Ether Cyclizations within a π-Basic Capsule Compared to Autocatalysis on π-Acidic Surfaces and Pnictogen-Bonding Catalysts’, Chemistry - A European Journal, 27(47), pp. 12215–12223. Available at: https://doi.org/10.1002/chem.202101548.

Heilmann, Michael et al. (2021) ‘Understanding the binding properties of phosphorylated glycoluril-derived molecular tweezers and selective nanomolar binding of natural polyamines in aqueous solution’, Organic and Biomolecular Chemistry, 19(16), pp. 3628–3633. Available at: https://doi.org/10.1039/d1ob00379h.

Merget, Severin et al. (2021) ‘Concentration-Dependent Self-Assembly of an Unusually Large Hexameric Hydrogen-Bonded Molecular Cage’, Chemistry - A European Journal, 27(13), pp. 4447–4453. Available at: https://doi.org/10.1002/chem.202005046.

Nemat, Suren and Tiefenbacher, Konrad (2021) ‘Thioderivatives of Resorcin[4]arene and Pyrogallol[4]arene: Are Thiols Tolerated in the Self-Assembly Process?’, Organic Letters, 23(17), pp. 6861–6865. Available at: https://doi.org/10.1021/acs.orglett.1c02426.

Pfeuffer-Rooschüz, Jonathan et al. (2021) ‘Xanthene[n]arenes: Exceptionally Large, Bowl-Shaped Macrocyclic Building Blocks Suitable for Self-Assembly’, JACS Au, 1(11), pp. 1885–1891. Available at: https://doi.org/10.1021/jacsau.1c00343.

Sokolova, Daria and Tiefenbacher, Konrad (2021) ‘Optimized iminium-catalysed 1,4-reductions inside the resorcinarene capsule: achieving >90% ee with proline as catalyst’, RSC Advances, 11(40), pp. 24607–24612. Available at: https://doi.org/10.1039/d1ra04333a.

Syntrivanis, Leonidas-Dimitrios and Tiefenbacher, Konrad (2021) ‘Catalysis Inside the Hexameric Resorcinarene Capsule: Toward Addressing Current Challenges in Synthetic Organic Chemistry’. wiley, pp. 321–334. Available at: https://doi.org/10.1002/9783527832033.ch22.

Knezevic, Melina et al. (2020) ‘Überwindung der intrinsischen Reaktivität bei aliphatischer C‐H‐Oxidation: Bevorzugte C3/C4‐Oxidation von aliphatischen Ammoniumsubstraten’, Angewandte Chemie. 26.05.2020, 132(30), pp. 12486–12490. Available at: https://doi.org/10.1002/ange.202004242.

Bissegger, Fabian R., Neuburger, Markus. and Tiefenbacher, Konrad (2020) ‘Scope of the direct trimerisation to C3-symmetric cyclotribenzylene derivatives’, Supramolecular Chemistry, 32(5), pp. 320–324. Available at: https://doi.org/10.1080/10610278.2020.1725514.

Knezevic, Melina et al. (2020) ‘Overriding Intrinsic Reactivity in Aliphatic C-H Oxidation: Preferential C3/C4 Oxidation of Aliphatic Ammonium Substrate’, Angewandte Chemie International Edition, 59(30), pp. 12387–12391. Available at: https://doi.org/10.1002/anie.202004242.

Merget, Severin et al. (2020) ‘Requirements for Terpene Cyclizations inside the Supramolecular Resorcinarene Capsule: Bound Water and its Protonation Determine the Catalytic Activit’, Journal of the American Chemical Society, 142(9), pp. 4400–4410. Available at: https://doi.org/10.1021/jacs.9b13239.

Nemat, Suren et al. (2020) ‘Catechol[4]arene: The Missing Chiral Member of the Calix[4]arene Family’, Organic Letters, 22(14), pp. 5506–5510. Available at: https://doi.org/10.1021/acs.orglett.0c01864.

Némethová, Ivana, Syntrivanis, Leonidas-Dimitrios and Tiefenbacher, Konrad (2020) ‘Molecular Capsule Catalysis: Ready to Address Current Challenges in Synthetic Organic Chemistry?’, Chimia, 74(7), pp. 561–568. Available at: https://doi.org/10.2533/chimia.2020.561.

Syntrivanis, Leonidas-Dimitrios et al. (2020) ‘Four-Step Access to the Sesquiterpene Natural Product Presilphiperfolan-1β-ol and Unnatural Derivatives via Supramolecular Catalysis’, Journal of the American Chemical Society, 142(12), pp. 5894–5900. Available at: https://doi.org/10.1021/jacs.0c01464.

Syntrivanis, Leonidas-Dimitrios et al. (2019) ‘Four-Step Access to the Sesquiterpene Natural Product Presilphiperfolan-1β-ol and Unnatural Derivatives via Supramolecular Catalysis’, Chemrxiv [Preprint]. Cambridge University Press (Chemrxiv). Available at: https://doi.org/10.26434/chemrxiv.9891341.v1.

Heilmann, Michael and Tiefenbacher, Konrad (2019) ‘A Modular Phosphorylated Glycoluril‐Derived Molecular Tweezer for Potent Binding of Aliphatic Diamines’, Chemistry - A European Journal, 25(56), pp. 12900–12904. Available at: https://doi.org/10.1002/chem.201902556.

Köster, Jesper, Häussinger, Daniel and Tiefenbacher, Konrad K. (2019) ‘Activation of primary and secondary benzylic and tertiary alkyl (sp3)C-F bonds inside a self-assembled molecular container’, Frontiers in Chemistry, 6, p. 639. Available at: https://doi.org/10.3389/fchem.2018.00639.

Pahima, Efrat et al. (2019) ‘Discovering Monoterpene Catalysis Inside Nanocapsules with Multiscale Modeling and Experiments’, Journal of the American Chemical Society, 141(15), pp. 6234–6246. Available at: https://doi.org/10.1021/jacs.8b13411.

Zhang, Qi et al. (2019) ‘En route to terpene natural products utilizing supramolecular cyclase mimetics’, Natural Product Reports, p. Epub. Available at: https://doi.org/10.1039/c9np00003h.

Zhang, Qi and Tiefenbacher, Konrad (2019) ‘Sesquiterpene Cyclizations inside the Hexameric Resorcinarene Capsule: Total Synthesis of δ‐Selinene and Mechanistic Studies’, Angewandte Chemie International Edition, 58(36), pp. 12688–12695. Available at: https://doi.org/10.1002/anie.201906753.

Catti, Lorenzo and Tiefenbacher, Konrad (2018) ‘Brønsted‐Säure‐katalysierte Carbonyl‐Olefin‐Metathese in einer selbstorganisierten supramolekularen Wirtstruktur’, Angewandte Chemie. 20.12.2017, 130(44), pp. 14797–14800. Available at: https://doi.org/10.1002/ange.201712141.

Catti, Lorenzo and Tiefenbacher, Konrad (2018) ‘Brønsted Acid-Catalyzed Carbonyl-Olefin Metathesis inside a Self-Assembled Supromolecular Host’, Angewandte Chemie International Edition, 57, pp. 14589–14592. Available at: https://doi.org/10.1002/anie.201712141.

Köster, J. and Tiefenbacher, K. (2018) ‘Elucidating the Importance of Hydrochloric Acid as a Cocatalyst for Resorcinarene-Capsule-Catalyzed reactions’, ChemCatChem, 10, p. 2941. Available at: https://doi.org/10.1002/cctc.201800326.

Thamm, Irene, Tiefenbacher, Konrad K. and Rychlik, Michael (2018) ‘Quantification of a-Thujone and its Metabolites in Human Urine after Consumption of a Sage Infusion Using Stable Isotope Dilution Assays’, Toxins, 10(12), pp. 1–10. Available at: https://doi.org/10.3390/toxins10120511.

Zhang, Qi, Catti, Lorenzo and Tiefenbacher, Konrad (2018) ‘Catalysis inside the Hexameric Resorcinarene Capsule’, Accounts of Chemical Research, 51(9), pp. 2107–2114. Available at: https://doi.org/10.1021/acs.accounts.8b00320.

Zhang, Qi et al. (2018) ‘Sesquiterpene cyclizations catalysed inside the resorcinarene capsule and application in the short synthesis of isolongifolene and isolongifolenone’, Nature Catalysis, 1(8), pp. 609–615. Available at: https://doi.org/10.1038/s41929-018-0115-4.

Bräuer, Thomas M., Zhang, Qi and Tiefenbacher, Konrad (2017) ‘Iminium Catalysis inside a Self-Assembled Supramolecular Capsule: Scope and Mechanistic Studies’, Journal of the American Chemical Society, 139(48), pp. 17500–17507. Available at: https://doi.org/10.1021/jacs.7b08976.

Catti, Lorenzo, Pöthig, Alexander and Tiefenbacher, Konrad (2017) ‘Host-Catalyzed Cyclodehydration-Rearrangement Cascade Reaction of Unsaturated Tertiary Alcohols’, Advanced Synthesis and Catalysis, 359(8), pp. 1331–1338. Available at: https://doi.org/10.1002/adsc.201601363.

Lou, Yu et al. (2017) ‘Design of stable Ni/ZrO2 catalysts for dry reforming of methane’, Journal of Catalysis, 356, pp. 147–156. Available at: https://doi.org/10.1016/j.jcat.2017.10.009.

Pollok, Corina H. et al. (2017) ‘Chirality induction from a chiral guest to the hydrogen bonding network of its hexameric resorcinarene host capsule’, ChemPhysChem, 18(15), pp. 1987–1991. Available at: https://doi.org/10.1002/cphc.201700610.

Richers, Johannes et al. (2017) ‘Synthesis and Neurotrophic Activity Studies of Illicium Sesquiterpene Natural Product Analogues’, Chemistry - A European Journal, 23(13), pp. 3178–3183. Available at: https://doi.org/10.1002/chem.201605362.

Richers, Johannes et al. (2017) ‘Synthesis and Neurotrophic Activity Studies of Illicium Sesquiterpene Natural Product Analogues’, Chemistry - A European Journal, 23(13), pp. 3178–3183. Available at: https://doi.org/10.1002/chem.201605362.

Zhang, Qi et al. (2017) ‘To catalyze or not to catalyze: elucidation of the subtle differences between the hexameric capsules of pyrogallolarene and resorcinarene’, Chemical Science, 8(2), pp. 1653–1657. Available at: https://doi.org/10.1039/c6sc04565k.

Zhang, Qi et al. (2017) ‘Terpene Cyclizations inside a Supramolecular Catalyst: Leaving Group-Controlled Product Selectivity and Mechanistic Studies’, Journal of the American Chemical Society, 139(33), pp. 11482–11492. Available at: https://doi.org/10.1021/jacs.7b04480.

Bräuer, Thomas M., Zhang, Qi and Tiefenbacher, Konrad (2016) ‘Iminiumkatalyse in einer selbstorganisierten supramolekularen Kapsel: Modulation des Enantiomerenüberschusses’, Angewandte Chemie. 03.06.2016, 128(27), pp. 7829–7832. Available at: https://doi.org/10.1002/ange.201602382.

Braeuer, Thomas M., Zhang, Qi and Tiefenbacher, Konrad (2016) ‘Iminium Catalysis inside a Self-Assembled Supramolecular Capsule: Modulation of Enantiomeric Excess’, Angewandte Chemie International Edition, 55(27), pp. 7698–701. Available at: https://doi.org/10.1002/anie.201602382.

Catti, Lorenzo et al. (2016) ‘Exploring Catalysis inside Self-assembled Supramolecular Containers’, Chimia, 70(11), pp. 810–814. Available at: https://doi.org/10.2533/chimia.2016.810.

Catti, Lorenzo, Zhang, Qi and Tiefenbacher, Konrad (2016) ‘Advantages of Catalysis in Self-Assembled Molecular Capsules’, Chemistry - A European Journal, 22(27), pp. 9060–6. Available at: https://doi.org/10.1002/chem.201600726.

Catti, Lorenzo, Zhang, Qi and Tiefenbacher, Konrad (2016) ‘Self-Assembled Supramolecular Structures as Catalysts for Reactions Involving Cationic Transition States’, Synthesis, pp. 313–328. Available at: https://doi.org/10.1055/s-0035-1560362.

Richers, Johannes et al. (2016) ‘Synthesis of Lactones via C−H Functionalization of Nonactivated C(sp ³ )−H Bonds’, Organic Letters, 18(24), pp. 6472–6475. Available at: https://doi.org/10.1021/acs.orglett.6b03371.

Thamm, Irene et al. (2016) ‘A six-step total synthesis of α-thujone and d6-α-thujone, enabling facile access to isotopically labelled metabolites’, Chemical Communications, 52(78), pp. 11701–11703. Available at: https://doi.org/10.1039/c6cc05376a.