Publications
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Peng, Jiaming et al. (2023) ‘Enzymatic Fluoromethylation as a Tool for ATP‐Independent Ligation’, Angewandte Chemie International Edition. 13.11.2023, 63(1). Available at: https://doi.org/10.1002/anie.202312104.
Reed, John H. and Seebeck, Florian P. (2023) ‘Reagent Engineering for Group Transfer Biocatalysis’, Angewandte Chemie International Edition. 09.09.2023, 63(7). Available at: https://doi.org/10.1002/anie.202311159.
Gericke, Lukas et al. (2023) ‘Biomimetic S-Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes’, ChemBioChem, 24(9). Available at: https://doi.org/10.1002/cbic.202300133.
Hartmann, Lea et al. (2023) ‘Isotope-labeled ergothioneine clarifies the mechanism of reaction with singlet oxygen’, Free Radical Biology and Medicine. 02.02.2023, 198, pp. 12–26. Available at: https://doi.org/10.1016/j.freeradbiomed.2023.01.023.
Beliaeva, Mariia A., Atac, Reyhan and Seebeck, Florian P. (2022) ‘Bacterial Degradation of Nτ-Methylhistidine’, ACS Chemical Biology, 17(7), pp. 1989–1995. Available at: https://doi.org/10.1021/acschembio.2c00437.
Beliaeva, Mariia A. and Seebeck, Florian P. (2022) ‘Discovery and Characterization of the Metallopterin-Dependent Ergothioneine Synthase from Caldithrix abyssi’, JACS Au, 2(9), pp. 2098–2107. Available at: https://doi.org/10.1021/jacsau.2c00365.
Wen, Xiaojin et al. (2022) ‘Synthetic Reagents for Enzyme-Catalyzed Methylation’, Angewandte Chemie International Edition, 61(41), p. e202208746. Available at: https://doi.org/10.1002/anie.202208746.
Beliaeva, Mariia A. et al. (2021) ‘In Vitro Production of Ergothioneine Isotopologues’, Angewandte Chemie International Edition, 60(10), pp. 5209–5212. Available at: https://doi.org/10.1002/anie.202011096.
Beliaeva, Mariia A., Leisinger, Florian and Seebeck, Florian P. (2021) ‘In Vitro Reconstitution of a Five-Step Pathway for Bacterial Ergothioneine Catabolism’, ACS Chemical Biology, 16(2), pp. 397–403. Available at: https://doi.org/10.1021/acschembio.0c00968.
Duncombe, Todd et al. (2021) ‘UV-Vis Spectra-Activated Droplet Sorting for Label-Free Chemical Identification and Collection of Drople’, Analytical Chemistry, 93(38), pp. 13008–13013. Available at: https://doi.org/10.1021/acs.analchem.1c02822.
Leisinger, Florian, Miarzlou , Dzmitry A. and Seebeck, Florian P. (2021) ‘Non-Coordinative Binding of O2 at the Active Center of a Copper-Dependent Enzyme’, Angewandte Chemie International Edition, 60(11), pp. 6154–6159. Available at: https://doi.org/10.1002/anie.202014981.
Peng, Jiaming et al. (2021) ‘Fluorinated S-Adenosylmethionine as a Reagent for Enzyme-Catalyzed Fluoromethylation’, Angewandte Chemie International Edition, 60(52), pp. 27178–27183. Available at: https://doi.org/10.1002/anie.202108802.
Schneider, Peter et al. (2021) ‘Biocatalytic C3-Indole Methylation-A Useful Tool for the Natural-Product-Inspired Stereoselective Synthesis of Pyrroloindoles’, Angewandte Chemie International Edition, 60(43), pp. 23412–23418. Available at: https://doi.org/10.1002/anie.202107619.
Flückger, Sebastian, Igareta, Nico V. and Seebeck, Florian P. (2020) ‘Convergent Evolution of Fungal Cysteine Dioxygenases’, ChemBioChem, 21(21), pp. 3082–3086. Available at: https://doi.org/10.1002/cbic.202000317.
Goncharenko, Kristina V. et al. (2020) ‘Selenocysteine as a Substrate, an Inhibitor and a Mechanistic Probe for Bacterial and Fungal Iron-Dependent Sulfoxide Synthases’, Chemistry - A European Journal, 26(6), pp. 1328–1334. Available at: https://doi.org/10.1002/chem.201903898.
Liao, Cangsong and Seebeck, Florian P. (2020) ‘Asymmetric β-Methylation of l- and d-α-Amino Acids by a Self-Contained Enzyme Cascade’, Angewandte Chemie International Edition, 59(18), pp. 7184–7187. Available at: https://doi.org/10.1002/anie.201916025.
Lim, David, Wen, Xiaojin and Seebeck, Florian P. (2020) ‘Selenoimidazolium Salts as Supramolecular Reagents for Protein Alkylation’, Chembiochem : a European journal of chemical biology, 21(24), pp. 3515–3520. Available at: https://doi.org/10.1002/cbic.202000557.
Maurer, Alice and Seebeck, Florian P. (2020) ‘Reexamination of the Ergothioneine Biosynthetic Methyltransferase EgtD from Mycobacterium tuberculosis as a Protein Kinase Substrate’, ChemBioChem, 21(20), pp. 2908–2911. Available at: https://doi.org/10.1002/cbic.202000232.
Milito, Alfonsina et al. (2020) ‘First evidence of ovothiol biosynthesis in marine diatoms’, Free radical biology and medicine, 152, pp. 680–688. Available at: https://doi.org/10.1016/j.freeradbiomed.2020.01.010.
Stampfli, Anja R., Blankenfeldt, Wulf and Seebeck, Florian P. (2020) ‘Structural basis of ergothioneine biosynthesis’, Current Opinion in Structural Biology, 65, pp. 1–8. Available at: https://doi.org/10.1016/j.sbi.2020.04.002.
Stampfli, Anja R. and Seebeck, Florian P. (2020) ‘The catalytic mechanism of sulfoxide synthases’, Current Opinion in Chemical Biology, 59, pp. 111–118. Available at: https://doi.org/10.1016/j.cbpa.2020.06.007.
Leisinger, Florian et al. (2019) ‘Structural and Mechanistic Basis for Anaerobic Ergothioneine Biosynthesis’, Journal of the American Chemical Society, 141(17), pp. 6906–6914. Available at: https://doi.org/10.1021/jacs.8b12596.
Liao, Cangsong and Seebeck, Florian P. (2019) ‘S-adenosylhomocysteine as a methyl transfer catalyst in biocatalytic methylation reactions’, Nature Catalysis, 2(8), pp. 696–701. Available at: https://doi.org/10.1038/s41929-019-0300-0.
Liao, Cangsong and Seebeck, Florian Peter (2019) ‘In vitro reconstitution of bacterial DMSP biosynthesis’, Angew. Chemie Int. Ed, 58(11), pp. 3553–3556. Available at: https://doi.org/10.1002/anie.201814662.
Lim, David, Gründemann, Dirk and Seebeck, Florian P. (2019) ‘Total Synthesis and Functional Characterization of Selenoneine’, Angewandte Chemie International Edition, 58(42), pp. 15026–15030. Available at: https://doi.org/10.1002/anie.201908967.
Maurer, Alice et al. (2019) ‘Structure and Mechanism of Ergothionase from Treponema denticola’, Chemistry - A European Journal, 25(44), pp. 10298–10303. Available at: https://doi.org/10.1002/chem.201901866.
Miarzlou, Dzmitry A. et al. (2019) ‘Structure of formylglycine-generating enzyme in complex with copper and a substrate reveals an acidic pocket for binding and activation of molecular oxygen’, Chemical Science, 10(29), pp. 7049–7058. Available at: https://doi.org/10.1039/c9sc01723b.
Stampfli, Anja R. et al. (2019) ‘An Alternative Active Site Architecture for O2 Activation in the Ergothioneine Biosynthetic EgtB from Chloracidobacterium thermophilum’, Journal of American Chemical Society, 141(13), pp. 5275–5285. Available at: https://doi.org/10.1021/jacs.8b13023.
Castellano, Immacolata and Seebeck, Florian P. (2018) ‘On ovothiol biosynthesis and biological roles: from life in the ocean to therapeutic potential’, Natural Product Reports, 35(12), pp. 1241–1250. Available at: https://doi.org/10.1039/c8np00045j.
Gamage, Akshamal M. et al. (2018) ‘The proteobacterial species Burkholderia pseudomallei produces ergothioneine, which enhances virulence in mammalian infection’, FASEB Journal, 32(12), pp. 6395–6409. Available at: https://doi.org/10.1096/fj.201800716.
Misson, Laëtitia et al. (2018) ‘Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtD’, ACS Chemical Biology, 13(5), pp. 1333–1342. Available at: https://doi.org/10.1021/acschembio.8b00127.
Burn, Reto et al. (2017) ‘Anaerobic Origin of Ergothioneine’, Angewandte Chemie International Edition, 56(41), pp. 12508–12511. Available at: https://doi.org/10.1002/anie.201705932.
Faponle, Abayomi S., Seebeck, Florian P. and de Visser, Sam P. (2017) ‘Sulfoxide Synthase versus Cysteine Dioxygenase Reactivity in a Nonheme Iron Enzyme’, Journal of the American Chemical Society, 139(27), pp. 9259–9270. Available at: https://doi.org/10.1021/jacs.7b04251.
Knop, Matthias et al. (2017) ‘Copper is a Cofactor of the Formylglycine-Generating Enzyme’, ChemBioChem, 18(2), pp. 161–165. Available at: https://doi.org/10.1002/cbic.201600359.
Knop, Matthias, Lemnaru, Roxana and Seebeck, Florian P. (2017) ‘Mutation of Conserved Residues Increases in Vitro Activity of the Formylglycine-Generating Enzyme.’, ChemBioChem, 18(17), pp. 1755–1761. Available at: https://doi.org/10.1002/cbic.201700174.
Liao, Cangsong and Seebeck, Florian P. (2017) ‘Convergent Evolution of Ergothioneine Biosynthesis in Cyanobacteria’, ChemBioChem, 18(21), pp. 2115–2118. Available at: https://doi.org/10.1002/cbic.201700354.
Meury, Marcel, Knop, Matthias and Seebeck, Florian P. (2017) ‘Structural Basis for Copper-Oxygen Mediated C-H Bond Activation by the Formylglycine-Generating Enzyme’, Angewandte Chemie International Edition, 56(28), pp. 8115–8119. Available at: https://doi.org/10.1002/anie.201702901.
Goncharenko, Kristina V and Seebeck, Florian P (2016) ‘Conversion of a non-heme iron-dependent sulfoxide synthase into a thiol dioxygenase by a single point mutation.’, Chemical Communications, 52(9), pp. 1945–8. Available at: https://doi.org/10.1039/c5cc07772a.
Lemnaru, Roxana (2016) A chemoenzymatic strategy for protein-nanocellulose conjugates. . Translated by Seebeck Florian Peter. Dissertation. Universität Basel.
Misson, Laetitia (2016) Insights into the mechansims and regluation of EgtD, a novel histidine methyltransferase from ergothioneine biosynthesis. . Translated by Seebeck Florian Peter. Dissertation. Universität Basel.
Goncharenko, Kristina V. et al. (2015) ‘Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway’, Angewandte Chemie International Edition, 54(9), pp. 2821–4. Available at: https://doi.org/10.1002/anie.201410045.
Knop, Matthias et al. (2015) ‘In Vitro Reconstitution of Formylglycine-Generating Enzymes Requires Copper(I)’, ChemBioChem, 16(15), pp. 2147–2150. Available at: https://doi.org/10.1002/cbic.201500322.
Vit, Allegra et al. (2015) ‘Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC’, ChemBioChem, 16(10), pp. 1490–6. Available at: https://doi.org/10.1002/cbic.201500168.
Vit, Allegra et al. (2015) ‘Ergothioneine Biosynthetic Methyltransferase EgtD Reveals the Structural Basis of Aromatic Amino Acid Betaine Biosynthesis’, ChemBioChem, 16(1), pp. 119–25. Available at: https://doi.org/10.1002/cbic.201402522.
Vit, Allegra et al. (2014) ‘Crystallization and preliminary X-ray analysis of the ergothioneine-biosynthetic methyltransferase EgtD’, Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 70(Pt 5), pp. 676–80. Available at: https://doi.org/10.1107/s2053230x1400805x.
Mashabela, Gabriel T M and Seebeck, Florian P (2013) ‘Substrate specificity of an oxygen dependent sulfoxide synthase in ovothiol biosynthesis’, Chemical Communications, 49(70), pp. 7714–6. Available at: https://doi.org/10.1039/c3cc42594k.
Seebeck, Florian (2013) ‘Thiohistidine biosynthesis’, Chimia, 67(5), pp. 333–336. Available at: https://doi.org/10.2533/chimia.2013.333.
Hofmann, Frank T., Szostak, Jack W. and Seebeck, Florian P. (2012) ‘In vitro selection of functional lantipeptides’, Journal of the American Chemical Society, 134(19), pp. 8038–8041. Available at: https://doi.org/10.1021/ja302082d.