Molecular Microbiology (Dehio)

Alter, Claudio Luca et al. (2025) ‘Nano Plasma Membrane Vesicle-Lipid Nanoparticle Hybrids for Enhanced Gene Delivery and Expression’, Advanced Healthcare Materials. 10.11.2024, 14(1). Available at: https://doi.org/10.1002/adhm.202401888.

Alaball Pujol, M.-E. (2025) Quantifying bacterial responses to antibiotics at the single-cell level.

Sedzicki, Jaroslaw et al. (2024) ‘Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens’, Nature Communications, 15(1). Available at: https://doi.org/10.1038/s41467-024-45415-8.

Ketterer, Maren et al. (2024) ‘The putative type 4 secretion system effector BspD is involved in maintaining envelope integrity of the pathogen Brucella’, mSphere, 9(11). Available at: https://doi.org/10.1128/msphere.00232-24.

Fromm, Katja et al. (2024) ‘Translocation of YopJ family effector proteins through the VirB/VirD4 T4SS of Bartonella’, bioRxiv [Preprint]. Cold Spring Harbor Laboratory (bioRxiv). Available at: https://doi.org/10.1101/2024.03.23.586424.

Ketterer, Maren et al. (2024) ‘The putative Type 4 secretion system effector BspD is involved in maintaining envelope integrity of the pathogen Brucella’, bioRxiv [Preprint]. Cold Spring Harbor Laboratory (bioRxiv). Available at: https://doi.org/10.1101/2024.03.18.585630.

Ketterer, M. (2024) Manipulation and survival: insights into strategies of the facultative intracellular pathogen ‘Brucella’.

Korotaev, A. (2024) From predator to partner: investigation of molecular mechanisms and function of ‘Bartonella’ Gene Transfer Agent.

Sollier, Julie et al. (2024) ‘Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions’, Nature Microbiology, 9(1), pp. 1–3. Available at: https://doi.org/10.1038/s41564-023-01566-w.

Kurmashev, Amanzhol et al. (2023) ‘Transwell-based microphysiological platform for high-resolution imaging of airway tissues’, bioRxiv [Preprint]. Cold Spring Harbor Laboratory (bioRxiv). Available at: https://doi.org/10.1101/2023.11.22.567838.

Verbeke, Jérémy et al. (2023) ‘Host cell egress of Brucella abortus requires BNIP3L-mediated mitophagy’, EMBO Journal, 42(14). Available at: https://doi.org/10.15252/embj.2022112817.

Ma, Fengjiao et al. (2023) ‘Guided-deconvolution for correlative light and electron microscopy’, PLoS ONE, 18(3 March). Available at: https://doi.org/10.1371/journal.pone.0282803.

Huber, M. (2023) Structure and function of Bartonella effector protein 1: target and interdomain interactions .

Alt, Silke et al. (2022) ‘INCATE: a partnership to boost the antibiotic pipeline’, Nature Reviews. Drug Discovery, 21(9), pp. 621–622. Available at: https://doi.org/10.1038/d41573-022-00138-7.

Fromm, Katja et al. (2022) ‘Bartonella taylorii; : A Model Organism for Studying; Bartonella; Infection; in vitro; and; in vivo;’, Frontiers in Microbiology, 13, p. 913434. Available at: https://doi.org/10.3389/fmicb.2022.913434.

Mode, Selma et al. (2022) ‘Antibiotic persistence of intracellular Brucella abortus’, PLoS Neglected Tropical Diseases, 16(7), p. e0010635. Available at: https://doi.org/10.1371/journal.pntd.0010635.

Sedzicki, Jaroslaw et al. (2022) ‘Mechanism of cyclic β-glucan export by ABC transporter Cgt of Brucella’, Nature Structural and Molecular Biology, 29(12), pp. 1170–1177. Available at: https://doi.org/10.1038/s41594-022-00868-7.

Siewert, Lena K., Dehio, Christoph and Pinschewer, Daniel D. (2022) ‘Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission’, PLoS Pathogens, 18(5), p. e1010489. Available at: https://doi.org/10.1371/journal.ppat.1010489.

Siewert, Lena K. et al. (2022) ‘Identification of the; Bartonella; autotransporter CFA as a protective antigen and hypervariable target of neutralizing antibodies in mice’, Proceedings of the National Academy of Sciences of the United States of America, 119(25), p. e2202059119. Available at: https://doi.org/10.1073/pnas.2202059119.

Dietz, Nikolaus et al. (2021) ‘Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1)’, Proceedings of the National Academy of Sciences, 118(12), p. e2023245118. Available at: https://doi.org/10.1073/pnas.2023245118.

Fromm, K. (2021) Modulation of the innate immune response during Bartonella infection.

Fromm, Katja and Dehio, Christoph (2021) ‘The Impact of; Bartonella; VirB/VirD4 Type IV Secretion System Effectors on Eukaryotic Host Cells’, Frontiers in Microbiology, 12, p. 762582. Available at: https://doi.org/10.3389/fmicb.2021.762582.

Marlaire, Simon and Dehio, Christoph (2021) ‘Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1’, PLoS pathogens, 17(1), p. e1008548. Available at: https://doi.org/10.1371/journal.ppat.1008548.

Marx, A.-F.M. (2021) The role of residual antigen and of the alarmin IL-33 in shaping the antiviral immune response.

Schirmer, Tilman et al. (2021) ‘Evolutionary Diversification of Host-Targeted; Bartonella; Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module’, Microorganisms, 9(8), p. 23. Available at: https://doi.org/10.3390/microorganisms9081645.

Tamegger, S. (2021) Structure - function studies on FIC - mediated AMPylation and deAMPylation by class I Fic proteins .

Dietz, Nikolaus Balthasar et al. (2020) ‘Structural basis for selective targeting of Rac subfamily GTPases by a bacterial effector protein’. bioRxiv. Available at: https://doi.org/10.1101/2020.06.29.167221.

Sorg, Isabel et al. (2020) ‘A Bartonella effector acts as signaling hub for intrinsic STAT3 activation to trigger anti-inflammatory responses’, Cell host & microbe, 27(3), pp. 476–485. Available at: https://doi.org/10.1016/j.chom.2020.01.015.

Barbier, C. (2019) New insights into the infection strategy of lineage 3 and lineage 4 Bartonella species. Available at: https://doi.org/10.5451/unibas-007169041.

Casanova, Alain et al. (2019) ‘A Role for the VPS Retromer in Brucella Intracellular Replication Revealed by Genomewide siRNA Screening’, mSphere, 4(3), pp. e00380–19. Available at: https://doi.org/10.1128/msphere.00380-19.

Dirmeier, Simon et al. (2019) ‘PyBDA: a command line tool for automated analysis of big biological data sets’, BMC bioinformatics, 20(1), p. 564. Available at: https://doi.org/10.1186/s12859-019-3087-8.

Liu, Yansheng et al. (2019) ‘Multi-omic measurements of heterogeneity in HeLa cells across laboratories’, Nature Biotechnology, 37(3), pp. 314–322. Available at: https://doi.org/10.1038/s41587-019-0037-y.

Mode, S. (2019) Assessing intracellular persister formation and antibiotics susceptibility in ‘Brucella abortus’. Available at: https://doi.org/10.5451/unibas-007198018.

Québatte, Maxime and Dehio, Christoph (2019) ‘Bartonella gene transfer agent: Evolution, function, and proposed role in host adaptation’, Cellular microbiology, 21(11), p. e13068. Available at: https://doi.org/10.1111/cmi.13068.

Siewert, L.K. (2019) Adaptive immunity in murine Bartonella infection. Available at: https://doi.org/10.5451/unibas-007132653.

Wagner, Alexander and Dehio, Christoph (2019) ‘Role of distinct type-IV-secretion systems and secreted effector sets in host adaptation by pathogenic Bartonella species’, Cellular microbiology, 21(3), p. e13004. Available at: https://doi.org/10.1111/cmi.13004.

Wagner, Alexander, Tittes, Colin and Dehio, Christoph (2019) ‘Versatility of the BID Domain: Conserved Function as Type-IV-Secretion-Signal and Secondarily Evolved Effector Functions Within; Bartonella; -Infected Host Cells’, Frontiers in Microbiology, 10, p. 921. Available at: https://doi.org/10.3389/fmicb.2019.00921.

Daga, Neha et al. (2018) ‘Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition’, Nucleic acids research, 46(18), pp. 9309–9320. Available at: https://doi.org/10.1093/nar/gky798.

Lobet, Elodie et al. (2018) ‘Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria’, Scientific reports, 8(1), p. 5173. Available at: https://doi.org/10.1038/s41598-018-23483-3.

Marlaire, S. (2018) Functional characterization of Bartonella effector protein C (BepC) in the context of infection. Available at: https://doi.org/10.5451/unibas-007133636.

Srivatsa, Sumana et al. (2018) ‘Improved pathway reconstruction from RNA interference screens by exploiting off-target effects’, Bioinformatics, 34(13), pp. i519–i527. Available at: https://doi.org/10.1093/bioinformatics/bty240.

Dehio, Christoph and Bumann, Dirk (2017) ‘Editorial overview: Bacterial systems biology’, Current Opinion in Microbiology, 39, pp. viii–xi. Available at: https://doi.org/10.1016/j.mib.2017.11.024.

Dehio, C. and Tsolis, R.M. (2017) ‘Type IV effector secretion and subversion of host functions by bartonella and brucella species’. Springer Verlagservice@springer.de, pp. 269–295. Available at: https://doi.org/10.1007/978-3-319-75241-9_11.

González-Prieto, Coral et al. (2017) ‘The Conjugative Relaxase TrwC Promotes Integration of Foreign DNA in the Human Genome’, Applied and Environmental Microbiology, 83(12), pp. e00207–17. Available at: https://doi.org/10.1128/aem.00207-17.

Harms, Alexander et al. (2017) ‘A bacterial toxin-antitoxin module is the origin of inter-bacterial and inter-kingdom effectors of Bartonella’, PLoS Genetics, 13(10), p. e1007077. Available at: https://doi.org/10.1371/journal.pgen.1007077.

Harms, Alexander et al. (2017) ‘Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella’, Genome biology and evolution, 9(3), pp. 761–776. Available at: https://doi.org/10.1093/gbe/evx042.

Omasits, Ulrich et al. (2017) ‘An integrative strategy to identify the entire protein coding potential of prokaryotic genomes by proteogenomics’, Genome Research, 27(12), pp. 2083–2095. Available at: https://doi.org/10.1101/gr.218255.116.

Québatte, Maxime et al. (2017) ‘Gene Transfer Agent Promotes Evolvability within the Fittest Subpopulation of a Bacterial Pathogen’, Cell Systems, 4(6), pp. 611–621.e6. Available at: https://doi.org/10.1016/j.cels.2017.05.011.

Québatte, Maxime and Dehio, Christoph (2017) ‘Systems-level interference strategies to decipher host factors involved in bacterial pathogen interaction: from RNAi to CRISPRi’, Current Opinion in Microbiology, 39, pp. 34–41. Available at: https://doi.org/10.1016/j.mib.2017.08.002.

Riba, Andrea et al. (2017) ‘Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results’, Cell Systems, 4(2), pp. 182–193. Available at: https://doi.org/10.1016/j.cels.2017.01.011.

Sędzicki, J. (2017) Correlative electron microscopy studies of the intracellular lifestyle of Brucella. Available at: https://doi.org/10.5451/unibas-006811828.

Andritschke, Daniel et al. (2016) ‘A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion’, PLoS ONE, 11(9), p. e0161965. Available at: https://doi.org/10.1371/journal.pone.0161965.

Casanova, Alain et al. (2016) ‘Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells’, Journal of Visualized Experiments, (114), p. e54263. Available at: https://doi.org/10.3791/54263.

Harms, Alexander, Stanger, Frédéric Valentin and Dehio, Christoph (2016) ‘Biological Diversity and Molecular Plasticity of FIC Domain Proteins’, Annual Reviews of Microbiology, pp. 341–60. Available at: https://doi.org/10.1146/annurev-micro-102215-095245.

Stanger, Frédéric V. et al. (2016) ‘Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin’, PLoS ONE, 11(9), p. e0163654. Available at: https://doi.org/10.1371/journal.pone.0163654.

Kallert, S. (2015) Interleukin-33 and vaccine vectors in virus-host balance. Available at: https://doi.org/10.5451/unibas-006413780.

Kreibich, Saskia et al. (2015) ‘Autophagy Proteins Promote Repair of Endosomal Membranes Damaged by the Salmonella Type Three Secretion System 1’, Cell host & microbe, 18(5), pp. 527–37. Available at: https://doi.org/10.1016/j.chom.2015.10.015.

Kühbacher, Andreas et al. (2015) ‘Genome-Wide siRNA Screen Identifies Complementary Signaling Pathways Involved in Listeria Infection and Reveals Different Actin Nucleation Mechanisms during Listeria Cell Invasion and Actin Comet Tail Formation’, mBio, 6(3), pp. e00598–15. Available at: https://doi.org/10.1128/mbio.00598-15.

Low, S.H. (2015) Genome-wide RNAi screen reveals host factors involved in ‘Brucella’ infection. Available at: https://doi.org/10.5451/unibas-006413768.

Lu, Y.-Y. (2015) Modulation of host immune responses by Bartonella effector proteins. Available at: https://doi.org/10.5451/unibas-006385039.

Schmich, Fabian et al. (2015) ‘Erratum to: gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens.’, Genome Biology, p. 233. Available at: https://doi.org/10.1186/s13059-015-0807-x.

Schmich, Fabian et al. (2015) ‘gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens’, Genome Biology, 16(220), p. 220. Available at: https://doi.org/10.1186/s13059-015-0783-1.

Siebourg-Polster, Juliane et al. (2015) ‘NEMix: single-cell nested effects models for probabilistic pathway stimulation’, PLoS Computational Biology, 11(4), p. e1004078. Available at: https://doi.org/10.1371/journal.pcbi.1004078.

Casanva, A. (2014) RNA interference screening identifies host factors involved in brucella infection. Available at: https://doi.org/10.5451/unibas-006658231.

Franceschini, Andrea et al. (2014) ‘Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens’, Proceedings of the National Academy of Sciences, 111(12), pp. 4548–53. Available at: https://doi.org/10.1073/pnas.1402353111.

Harms, A. (2014) FIC domain toxins are the origin of intra- and inter-kingdom effectors of Bartonella. Available at: https://doi.org/10.5451/unibas-006624952.

Okujava, Rusudan et al. (2014) ‘A translocated effector required for bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors’, PLoS Pathogens, 10(6). Available at: https://doi.org/10.1371/journal.ppat.1004187.

Pieles, K. (2014) From FIC to BID : target identification and functional characterization of ‘Bartonella’ effector proteins. Available at: https://doi.org/10.5451/unibas-006268682.

Pieles, Kathrin et al. (2014) ‘An experimental strategy for the identification of AMPylation targets from complex protein samples’, Proteomics, 14(9), pp. 1048–1052. Available at: https://doi.org/10.1002/pmic.201300470.

Québatte, M. (2014) Uncovering the transcriptional control of ‘Bartonella henselae’ host adaptation factors. Available at: https://doi.org/10.5451/unibas-006275781.

Rämö, Pauli et al. (2014) ‘Simultaneous analysis of large-scale RNAi screens for pathogen entry’, BMC Genomics, 15(1), p. 1162. Available at: https://doi.org/10.1186/1471-2164-15-1162.

Siamer, Sabrina and Dehio, Christoph (2014) ‘New insights into the role of Bartonella effector proteins in pathogenesis’, Current Opinion in Microbiology, pp. 80–5. Available at: https://doi.org/10.1016/j.mib.2014.11.007.

Stanger, Frédéric V., Dehio, Christoph and Schirmer, Tilman (2014) ‘Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis’, PLoS ONE, 9(9), p. e107289. Available at: https://doi.org/10.1371/journal.pone.0107289.

Stekhoven, Daniel J. et al. (2014) ‘Proteome-wide identification of predominant subcellular protein localizations in a bacterial model organism’, Journal of Proteomics, 99, pp. 123–37. Available at: https://doi.org/10.1016/j.jprot.2014.01.015.

Stekhoven, Daniel J. et al. (2014) ‘Proteome-wide identification of predominant subcellular protein localizations in a bacterial model organism’, Journal of Proteomics, 99, pp. 123–37. Available at: https://doi.org/10.1016/j.jprot.2014.01.015.

Alperi, A. et al. (2013) ‘A translocation motif in relaxase TrwC specifically affects recruitment by its conjugative Type IV Secretion System’, Journal of Bacteriology, 195(22), pp. 4999–5006. Available at: https://doi.org/10.1128/jb.00367-13.

Ben-Tekaya, H., Gorvel, J. P. and Dehio, C. (2013) ‘Bartonella and Brucella - weapons and strategies for stealth attack’, Cold Spring Harbor Perspectives in Medicine, 3(8), p. a010231. Available at: https://doi.org/10.1101/cshperspect.a010231.

Eicher, Simone C and Dehio, Christoph (2013) ‘Systems-level analysis of host-pathogen interaction using RNA interference’, New biotechnology, 30(3), pp. 308–13. Available at: https://doi.org/10.1016/j.nbt.2013.01.008.

Farhan, M. et al. (2013) ‘Multi-scale Gaussian representation and outline-learning based cell image segmentation’, BMC Bioinformatics, 14 Suppl 10(S10 S6), p. S6. Available at: https://doi.org/10.1186/1471-2105-14-s10-s6.

Goepfert, Arnaud et al. (2013) ‘Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with fic fold’, PLoS ONE, 8(5), p. e64901. Available at: https://doi.org/10.1371/journal.pone.0064901.

Kühbacher, Andreas et al. (2013) ‘Imaging InlC secretion to investigate cellular infection by the bacterial pathogen Listeria monocytogenes’, Journal of Visualized Experiments, 79(79), p. e51043. Available at: https://doi.org/10.3791/51043.

Okujava, R. (2013) Functional characterization of ‘Bartonella’ effector protein - BepE during ‘in vivo’ and ‘in vitro’ infection. Available at: https://doi.org/10.5451/unibas-006136904.

Omasits, U. et al. (2013) ‘Directed shotgun proteomics guided by saturated RNA-seq identifies a complete expressed prokaryotic proteome’, Genome Research, 23(11), pp. 1916–27. Available at: https://doi.org/10.1101/gr.151035.112.

Québatte, Maxime et al. (2013) ‘Dual input control : activation of the Bartonella henselae VirB/D4 type IV secretion system by the stringent sigma factor RpoH1 and the BatR/BatS two-component system’, Molecular microbiology, 90(4), pp. 756–75. Available at: https://doi.org/10.1111/mmi.12396.

Rolain, J. M. et al. (2013) ‘Partial disruption of translational and posttranslational machinery reshapes growth rates of Bartonella birtlesii’, mBio, 4(2), pp. e00115–13. Available at: https://doi.org/10.1128/mbio.00115-13.

Köberle, Martin et al. (2012) ‘Yersinia enterocolitica YopT and Clostridium difficile Toxin B Induce Expression of GILZ in Epithelial Cells’, PLoS ONE, 7(7), p. e40730. Available at: https://doi.org/10.1371/journal.pone.0040730.

Dehio, C., Berry, C. and Bartenschlager, R. (2012) ‘Persistent intracellular pathogens’, FEMS Microbiology Reviews, 36(3), p. 513. Available at: https://doi.org/10.1111/j.1574-6976.2012.00336.x.

Eicher, S. C. and Dehio, C. (2012) ‘Bartonella entry mechanisms into mammalian host cells’, Cellular Microbiology, 14(8), pp. 1166–73. Available at: https://doi.org/10.1111/j.1462-5822.2012.01806.x.

Harms, Alexander and Dehio, Christoph (2012) ‘Intruders below the Radar : Molecular Pathogenesis of Bartonella spp’, Clinical microbiology reviews, 25(1), pp. 42–78. Available at: https://doi.org/10.1128/cmr.05009-11.

Llosa, M., Schröder, G. and Dehio, C. (2012) ‘New perspectives into bacterial DNA transfer to human cells’, Trends in Microbiology, 20(8), pp. 355–9. Available at: https://doi.org/10.1016/j.tim.2012.05.008.

Lu, Y. Y. et al. (2012) ‘Bartonella henselae trimeric autotransporter adhesin BadA expression interferes with effector translocation by the VirB/D4 type IV secretion system’, Cellular microbiology, 15(5), pp. 759–78. Available at: https://doi.org/10.1111/cmi.12070.

Pulliainen, Arto Tapio and Dehio, Christoph (2012) ‘Persistence of Bartonella spp. stealth pathogens : from subclinical infections to vasoproliferative tumor formation’, FEMS Microbiology Reviews, 36(3), pp. 563–599. Available at: https://doi.org/10.1111/j.1574-6976.2012.00324.x.

Pulliainen, A. T. et al. (2012) ‘Bacterial effector binds host cell adenylyl cyclase to potentiate Gαs-dependent cAMP production’, Proceedings of the National Academy of Sciences of the United States of America, 109(24), pp. 9581–6. Available at: https://doi.org/10.1073/pnas.1117651109.

Rouilly, Vincent et al. (2012) ‘iBRAIN2: automated analysis and data handling for RNAi screens’, Studies in health technology and informatics, 175, pp. 205–213. Available at: https://doi.org/10.3233/978-1-61499-054-3-205.

Engel, P. (2011) A genomic approach to the role of type IV secretion systems in Bartonella host adaption. Available at: https://doi.org/10.5451/unibas-005591093.

Kim, M. L., Sorg, I. and Arrieumerlou, C. (2011) ‘Endocytosis-Independent Function of Clathrin Heavy Chain in the Control of Basal NF-kappaB Activation’, PLoS ONE, 6(2). Available at: https://doi.org/10.1371/journal.pone.0017158.

Engel, Philipp et al. (2011) ‘Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella.’, PLoS Genetics, 7(2), p. e1001296. Available at: https://doi.org/10.1371/journal.pgen.1001296.

Fernández-González, Esther et al. (2011) ‘Transfer of R388 derivatives by a pathogenesis-associated type IV secretion system into both bacteria and human cells’, Journal of bacteriology, 193(22), pp. 6257–65. Available at: https://doi.org/10.1128/jb.05905-11.

Mietze, A. et al. (2011) ‘Combined MLST and AFLP typing of Bartonella henselae isolated from cats reveals new sequence types and suggests clonal evolution’, Veterinary Microbiology, 148(2-4), pp. 238–45. Available at: https://doi.org/10.1016/j.vetmic.2010.08.012.

Palanivelu, D. V. et al. (2011) ‘Fic domain catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA’, Protein Science, 20(3), pp. 492–9. Available at: https://doi.org/10.1002/pro.581.