UNIverse - Public Research Portal

Computational & Translational Pathology Lab

Publications

72 found
Show per page

van den Berg, Nikki et al. (2026) ‘Deep Learning-Based Screening for POLE mutations on Histopathology Slides in Endometrial Cancer’, medRxiv [Preprint]. (medRxiv). Available at: https://doi.org/10.64898/2026.02.06.26345335.

URLs
URLs

Bräutigam, Konstantin et al. (2026) ‘Integrating artificial intelligence ( AI ) into colorectal cancer reporting’, Journal of Pathology [Preprint]. Available at: https://doi.org/10.1002/path.70029.

URLs
URLs

Chen, Boqi et al. (2026) ‘Revisiting Automatic Data Curation for Vision Foundation Models in Digital Pathology’, in Lecture Notes in Computer Science. Cham: Springer Science and Business Media Deutschland GmbH (Lecture Notes in Computer Science), pp. 554–564. Available at: https://doi.org/10.1007/978-3-032-04978-0_53.

URLs
URLs

Gosztonyi, Benedict et al. (2026) ‘Safety of Multi-Omics–Guided Therapy in Advanced Melanoma: A Matched Comparative Cohort Analysis’, JCO Precision Oncology, 10(1). Available at: https://doi.org/10.1200/po-25-00896.

URLs
URLs

Pnev, S. et al. (2026) ‘Scheduled Cross-Domain Multi-center DINO for Robust High-Content Screening Representation Learning’, in Lecture Notes in Computer Science. Cham: Springer Science and Business Media Deutschland GmbH (Lecture Notes in Computer Science), pp. 432–441. Available at: https://doi.org/10.1007/978-3-032-09513-8_42.

URLs
URLs

Frei, Céline Arlette et al. (2025) ‘The chromatin guardian ATRX is a strong prognostic biomarker in melanoma’, Scientific Reports, 16(1). Available at: https://doi.org/10.1038/s41598-025-30842-4.

Mehra, Tarun et al. (2025) ‘Comparative cost analysis of a diagnostic multi-omics platform for decision support in advanced cancer – results from the Tumor Profiler Melanoma project’, npj Precision Oncology, 10(1). Available at: https://doi.org/10.1038/s41698-025-01229-5.

Sakalauskaite, Gabriele et al. (2025) ‘A BioID-based approach uncovers the interactome of hexose-6-phosphate dehydrogenase in breast cancer cells and identifies anterior gradient protein 2 as an interacting partner’, Cell and Bioscience, 15(1). Available at: https://doi.org/10.1186/s13578-025-01388-9.

URLs
URLs

Shin, JaeWoong et al. (2025) ‘OCELOT 2023: Cell detection from cell–tissue interaction challenge’, Medical Image Analysis. 07.08.2025, 106. Available at: https://doi.org/10.1016/j.media.2025.103751.

URLs
URLs

Schmid, Dominic et al. (2025) ‘Tumor immune dynamics and long-term clinical outcome of stage IIIA NSCLC patients treated with neoadjuvant chemoimmunotherapy’, Nature Communications, 16(1). Available at: https://doi.org/10.1038/s41467-025-63696-5.

Nonchev, K. et al. (2025) ‘DeepSpot2Cell: Predicting Virtual Single-Cell Spatial Transcriptomics from H&E images using Spot-Level Supervision’. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2025.09.23.678121.

URLs
URLs

Wiesmann, F. et al. (2025) ‘RIPPLET: Mutation-Only Gene and Pathway Profiling for Precision Oncology’. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2025.09.17.676675.

URLs
URLs

Fusi, Irene et al. (2025) ‘PD-1–targeted cis-delivery of an IL-2 variant induces a multifaceted antitumoral T cell response in human lung cancer’, Science Translational Medicine, 17(816). Available at: https://doi.org/10.1126/scitranslmed.adr3718.

URLs
URLs

Zajac, N. et al. (2025) ‘Comparison of single-cell long-read and short-read transcriptome sequencing via cDNA molecule matching: quality evaluation of the MAS-ISO-seq approach’, 7. Available at: https://doi.org/10.1093/nargab/lqaf089.

URLs
URLs

Bräutigam, Konstantin et al. (2025) ‘Spatially resolved analysis of TGF/BMP signalling in pancreatic ductal adenocarcinoma by digital pathology identifies patient subgroups with adverse outcome’, BMC Cancer, 25(1). Available at: https://doi.org/10.1186/s12885-025-14751-3.

URLs
URLs

Andani, Sonali et al. (2025) ‘Histopathology-based protein multiplex generation using deep learning’, Nature Machine Intelligence, 7(8), pp. 1292–1307. Available at: https://doi.org/10.1038/s42256-025-01074-y.

Litchfield, Cassandra et al. (2025) ‘Integrating Formalin-Fixed, Paraffin-Embedded–Derived Whole-Genome Sequencing into Routine Molecular Pathology: Validation and First Experiences in Metastatic Melanoma’, Journal of Molecular Diagnostics, 27, pp. 722–735. Available at: https://doi.org/10.1016/j.jmoldx.2025.04.011.

URLs
URLs

Schoenpflug, Lydia A. et al. (2025) ‘Navigating real-world challenges: A case study on federated learning in computational pathology’, Journal of Pathology Informatics, 18. Available at: https://doi.org/10.1016/j.jpi.2025.100464.

URLs
URLs

Berg, I., Wu, J. and Koelzer, V.H. (2025) ‘Generative cerebral vasculature visualization using spatial transcriptomic data’. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2025.07.10.664153.

URLs
URLs

Miglino, Nicola et al. (2025) ‘Feasibility of multiomics tumor profiling for guiding treatment of melanoma’, Nature Medicine, 31, pp. 2430–2441. Available at: https://doi.org/10.1038/s41591-025-03715-6.

URLs
URLs

Rubin, David T et al. (2025) ‘Deployment of an Artificial Intelligence Histology Tool to Aid Qualitative Assessment of Histopathology Using the Nancy Histopathology Index in Ulcerative Colitis’, Inflammatory Bowel Diseases, 31(6), pp. 1630–1636. Available at: https://doi.org/10.1093/ibd/izae204.

Karakulak, T. et al. (2025) ‘Heterogeneous and novel transcript expression in single cells of patient-derived clear cell renal cell carcinoma organoids’, 35. Available at: https://doi.org/10.1101/gr.279345.124.

URLs
URLs

Nonchev, Kalin et al. (2025) ‘DeepSpot: Leveraging Spatial Context for Enhanced Spatial Transcriptomics Prediction from H&E Images’, in Neural Information Processing Systems (NeurIPS). Mexico: Cold Spring Harbor Laboratory (Neural Information Processing Systems (NeurIPS)), pp. 1–10. Available at: https://doi.org/10.1101/2025.02.09.25321567.

URLs
URLs

Schoenpflug, Lydia A et al. (2025) ‘Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis’, Journal of Pathology, 265(2), pp. 184–197. Available at: https://doi.org/10.1002/path.6376.

URLs
URLs

Palles, Claire et al. (2025) ‘Comparison between germline and somatic loss-of-function RNF43 mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis’, Gut [Preprint]. 24.12.2025. Available at: https://doi.org/10.1136/gutjnl-2025-337030.

URLs
URLs

Wu,Jiqing, Berg,Ingrid and Koezler,Viktor H. (2025) ‘Generative cerebral vasculature visualization using spatial transcriptomic data’, bioRxiv (Cold Spring Harbor Laboratory) [Preprint].

Wu,Jiqing et al. (2025) ‘Tera-MIND: Tera-scale mouse brain simulation via spatial mRNA-guided diffusion’, arXiv (Cornell University) [Preprint].

Vledder, Annegé et al. (2024) ‘B cells critical for outcome in high grade serous ovarian carcinoma’, International Journal of Cancer, 155(12), pp. 2265–2276. Available at: https://doi.org/10.1002/ijc.35149.

URLs
URLs

Eerkens, Anneke L. et al. (2024) ‘Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study’, Nature Communications , 15(1). Available at: https://doi.org/10.1038/s41467-024-52098-8.

URLs
URLs

Fan, Fan et al. (2024) ‘CohortFinder: an open-source tool for data-driven partitioning of digital pathology and imaging cohorts to yield robust machine-learning models’, npj Imaging, 2(1). Available at: https://doi.org/10.1038/s44303-024-00018-2.

URLs
URLs

Lafarge, Maxime W. et al. (2024) ‘Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy’, npj Precision Oncology, 8(1). Available at: https://doi.org/10.1038/s41698-024-00580-3.

URLs
URLs

Schoenpflug, Lydia A. et al. (2024) ‘A review on federated learning in computational pathology’, Computational and Structural Biotechnology Journal, 23, pp. 3938–3945. Available at: https://doi.org/10.1016/j.csbj.2024.10.037.

URLs
URLs

Wegmann, Rebekka et al. (2024) ‘Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia’, Nature Communications , 15(1). Available at: https://doi.org/10.1038/s41467-024-53535-4.

URLs
URLs

Wu, Jiqing and Koelzer, Viktor H. (2024) ‘Towards generative digital twins in biomedical research’, Computational and Structural Biotechnology Journal, 23, pp. 3481–3488. Available at: https://doi.org/10.1016/j.csbj.2024.09.030.

URLs
URLs

Wu, Jiqing and Koelzer, Viktor H. (2024) ‘Towards generative digital twins in biomedical research’, Computational and Structural Biotechnology Journal, 23, pp. 3481–3488. Available at: https://doi.org/10.1016/j.csbj.2024.09.030.

Sobottka, Bettina et al. (2024) ‘Immune Phenotype-Genotype Associations in Primary Clear Cell Renal Cell Carcinoma and Matched Metastatic Tissue’, Modern Pathology, 37(10). Available at: https://doi.org/10.1016/j.modpat.2024.100558.

URLs
URLs

Roth, Lilian et al. (2024) ‘CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC)’, Scientific Reports, 14(1). Available at: https://doi.org/10.1038/s41598-024-72826-w.

URLs
URLs

Nowak, Marta et al. (2024) ‘Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer’, Cell Reports Medicine, 5(9). Available at: https://doi.org/10.1016/j.xcrm.2024.101727.

URLs
URLs

Huellner, M.W. et al. (2024) ‘Distinct [18F]FDG-PET imaging features of a newly recognized and yet uncharacterized RDD-ECD overlap disease entity’, European Journal of Nuclear Medicine and Molecular Imaging, 51(11), pp. 3465–3466. Available at: https://doi.org/10.1007/s00259-024-06751-5.

URLs
URLs

Wu, Jiqing and Koelzer, Viktor H. (2024) ‘GILEA: In silico phenome profiling and editing using GAN Inversion’, Computers in Biology and Medicine, 179. Available at: https://doi.org/10.1016/j.compbiomed.2024.108825.

URLs
URLs

Domingo, Enric et al. (2024) ‘Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictors’, eBioMedicine. 16.07.2024, 106. Available at: https://doi.org/10.1016/j.ebiom.2024.105228.

URLs
URLs

Immer, Alexander et al. (2024) ‘Probabilistic pathway-based multimodal factor analysis’, Bioinformatics, 40(Supplement_1), pp. i189–i198. Available at: https://doi.org/10.1093/bioinformatics/btae216.

Janowczyk, Andrew et al. (2024) ‘Swiss digital pathology recommendations: results from a Delphi process conducted by the Swiss Digital Pathology Consortium of the Swiss Society of Pathology’, Virchows Archiv, 485(1), pp. 13–30. Available at: https://doi.org/10.1007/s00428-023-03712-5.

URLs
URLs

Mahmood, Umair et al. (2024) ‘Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures’, Cancer Research Communications, 4(7), pp. 1765–1776. Available at: https://doi.org/10.1158/2767-9764.crc-23-0502.

URLs
URLs

Mahmood ,Umair et al. (2024) ‘Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures’, Cancer Research Communications, 4(7), pp. 1765–1776. Available at: https://doi.org/10.1158/2767-9764.CRC-23-0502.

Volinsky-Fremond, Sarah et al. (2024) ‘Author Correction: Prediction of recurrence risk in endometrial cancer with multimodal deep learning (Nature Medicine, (2024), 30, 7, (1962-1973), 10.1038/s41591-024-02993-w)’, Nature Medicine, 30(7), p. 2092. Available at: https://doi.org/10.1038/s41591-024-03126-z.

URLs
URLs

Volinsky-Fremond, Sarah et al. (2024) ‘Prediction of recurrence risk in endometrial cancer with multimodal deep learning’, Nature Medicine, 30(7), pp. 1962–1973. Available at: https://doi.org/10.1038/s41591-024-02993-w.

URLs
URLs

Domingo, Enric et al. (2024) ‘Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies’, Journal of Clinical Oncology. 14.03.2024, 42(18), pp. 2207–2218. Available at: https://doi.org/10.1200/jco.23.01648.

URLs
URLs

Malla, Sudhir B. et al. (2024) ‘Correction to: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer (Nature Genetics, (2024), 56, 3, (458-472), 10.1038/s41588-024-01654-5)’, Nature Genetics, 56(6), p. 1321. Available at: https://doi.org/10.1038/s41588-024-01809-4.

URLs
URLs

Wakkerman, Famke C et al. (2024) ‘Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials’, The Lancet Oncology, 25(6), pp. 779–789. Available at: https://doi.org/10.1016/s1470-2045(24)00142-6.

URLs
URLs

Aubreville, Marc et al. (2024) ‘Domain generalization across tumor types, laboratories, and species — Insights from the 2022 edition of the Mitosis Domain Generalization Challenge’, Medical Image Analysis, 94. Available at: https://doi.org/10.1016/j.media.2024.103155.

URLs
URLs

Zajac, N. et al. (2024) ‘Comparison of Single-cell Long-read and Short-read Transcriptome Sequencing of Patient-derived Organoid Cells of ccRCC: Quality Evaluation of the MAS-ISO-seq Approach’. Cold Spring Harbor Laboratory. Available at: https://doi.org/10.1101/2024.03.14.584953.

URLs
URLs

Malla, Sudhir B. et al. (2024) ‘Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer’, Nature Genetics, 56(3), pp. 458–472. Available at: https://doi.org/10.1038/s41588-024-01654-5.

URLs
URLs

Nasreddin, Nadia et al. (2024) ‘Poor Diagnostic Reproducibility in the Identification of Nonconventional Dysplasia in Colitis Impacts the Application of Histologic Stratification Tools’, Modern Pathology, 37(3). Available at: https://doi.org/10.1016/j.modpat.2023.100419.

URLs
URLs

Wu, Jiqing and Koelzer, Viktor H. (2024) ‘SST-editing: in silico spatial transcriptomic editing at single-cell resolution’, Bioinformatics, 40(3). Available at: https://doi.org/10.1093/bioinformatics/btae077.

URLs
URLs

Frei, Anja L et al. (2024) ‘Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis’, The Lancet Oncology, 25(2), pp. 198–211. Available at: https://doi.org/10.1016/s1470-2045(23)00560-0.

URLs
URLs

Frei, Anja L et al. (2024) ‘Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II-III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis’, The Lancet Oncology. 29.01.2024, 25(2), pp. 198–211. Available at: https://doi.org/10.1016/S1470-2045(23)00560-0.

Dlamini, Z., Ladomery, M.R. and Kahraman, A. (2024) ‘Editorial: The RNA revolution and cancer’, 15. Available at: https://doi.org/10.3389/fendo.2024.1422599.

URLs
URLs

Jiqing, Wu, Ingrid, Berg and Viktor Koelzer (2024) ‘IST-editing: Infinite spatial transcriptomic editing in a generated gigapixel mouse pup’, in Medical Imaging with Deep Learning 2024. France (Medical Imaging with Deep Learning 2024).

Lafarge, Maxime W. and Koelzer, Viktor Hendrik (2024) ‘Detecting Cells in Histopathology Images with a ResNet Ensemble Model’, in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Springer Science and Business Media Deutschland GmbH (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)), pp. 123–129. Available at: https://doi.org/10.1007/978-3-031-55088-1_11.

URLs
URLs

Schoenpflug, L.A. and Koelzer, V.H. (2024) ‘SoftCTM: Cell Detection by Soft Instance Segmentation and Consideration of Cell-Tissue Interaction’, in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Springer Science and Business Media Deutschland GmbH (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)), pp. 109–122. Available at: https://doi.org/10.1007/978-3-031-55088-1_10.

URLs
URLs

Wakkerman, Famke C, Wu, Jiqing et al. (2024) ‘Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials’, The Lancet Oncology, pp. 779–789. Available at: https://doi.org/10.1016/S1470-2045(24)00142-6 .

Wood, Ruby et al. (2024) ‘Cluster Triplet Loss for Unsupervised Domain Adaptation on Histology Images’, in IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops. IEEE Computer Society (IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops), pp. 5122–5131. Available at: https://doi.org/10.1109/cvprw63382.2024.00519.

URLs
URLs

Brouwer, Nelleke PM et al. (2023) ‘Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer’, Journal of Pathology, 261(4), pp. 401–412. Available at: https://doi.org/10.1002/path.6196.

URLs
URLs

Dondi, Arthur et al. (2023) ‘Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer’, Nature Communications, 14(1). Available at: https://doi.org/10.1038/s41467-023-43387-9.

URLs
URLs

Grobholz, Rainer et al. (2023) ‘National digital pathology projects in Switzerland: A 2023 update’, Pathologie, 44, pp. 225–228. Available at: https://doi.org/10.1007/s00292-023-01259-5.

URLs
URLs

Frei, Anja L et al. (2023) ‘Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets’, Journal of Pathology: Clinical Research, 9(6), pp. 449–463. Available at: https://doi.org/10.1002/cjp2.342.

URLs
URLs

Marques-Maggio, Ewerton et al. (2023) ‘Bone marrow haematopoiesis in patients with COVID-19’, Histopathology, 83(4), pp. 582–590. Available at: https://doi.org/10.1111/his.14969.

URLs
URLs

Wagner, Sophia J. et al. (2023) ‘Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study’, Cancer Cell, 41(9), pp. 1650–1661.e4. Available at: https://doi.org/10.1016/j.ccell.2023.08.002.

URLs
URLs

Kahraman, A. and Thornton, J.M. (2008) ‘Methods to Characterize the Structure of Enzyme Binding Sites’, in COMPUTATIONAL STRUCTURAL BIOLOGY - METHODS AND APPLICATIONS. (COMPUTATIONAL STRUCTURAL BIOLOGY - METHODS AND APPLICATIONS), pp. 189–221.

Kahraman, A. et al. (2007) ‘Variation of geometrical and phsicochemical properties in protein binding pockets and their ligands’, in Third International Society for Computational Biology (ISCB) Student Council Symposium at the Fifteenth Annual International Conference on Intel-ligent Systems for Molecular Biology (ISMB). Vienna, Austria (Third International Society for Computational Biology (ISCB) Student Council Symposium at the Fifteenth Annual International Conference on Intel-ligent Systems for Molecular Biology (ISMB)), pp. 1–2. Available at: https://doi.org/10.1186/1471-2105-8-S8-S1.

Morris, R.J. et al. (2005) ‘Binding pocket shape analysis for protein function prediction’, in Quantitative Biology, Shape Analysis, and Wavelets. Leeds, UK (LASR (Leeds Annual Statistical Research) Workshop), pp. 91–94. Available at: https://http://www.bio.net/bionet/mm/bionews/2004-December/005880.html.